Combination CF Drugs Formoterol + Methacholine May Improve Mucus Clearance
Combining formoterol and methacholine significantly improves mucociliary clearance in animal models of cystic fibrosis, compared to using either drug alone.
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Combination CF Drugs Formoterol + Methacholine May Improve Mucus Clearance
Combining formoterol and methacholine significantly improves mucociliary clearance in animal models of cystic fibrosis, compared to using either drug alone.
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Cystic Fibrosis Patient Receives Quadruple Transplant
A 28-year-old cystic fibrosis patient underwent a 36-hour quadruple organ transplant for both lungs, a liver, and a kidney from a single donor.
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COVID-19 Outcomes in Cystic Fibrosis Transplant Patients
New research indicates that baseline lung health is a stronger predictor of SARS-CoV-2 outcomes in cystic fibrosis transplantation patients than the time elapsed since transplantation.
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FDA Approves Expanded Indications for CF Drugs Alyftrek, Trikafta
New label extensions for Alyftrek and Trikafta make approximately 95% of the cystic fibrosis population in the United States eligible for treatment.
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Nanoparticle-based Gene Editing for Cystic Fibrosis
Researchers developed lipid nanoparticles capable of inserting a full healthy CFTR gene into lab-grown human airway cells with severe cystic fibrosis.
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Quantitative Mucin Index: a New Metric to Monitor Lung Health
The Quantitative Mucin Index (MUCQ) of the Lung analyzes sputum and other lung mucus samples to detect airway mucus abnormalities, assess disease risk, and track disease progression in patients over time.
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Reevaluating Salt Intake for Cystic Fibrosis Patients
Researchers assessed salt intake in cystic fibrosis patients undergoing treatment with CFTR modulators, which improve salt conservation and other physiological markers.
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Progress for Cystic Fibrosis Early Diagnosis
A new report shows steady progress in identifying cystic fibrosis earlier, with 67% of CF infants screened in 2024 within the first 28 days of life, compared to 60% in 2014.
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Influenza’s Toll on Cystic Fibrosis Patients
UK patients with cystic fibrosis are being hit hard by a wave of influenza in the country.
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Prioritizing Prevention of Chronic Respiratory Diseases
ERS leaders are calling for health systems to prioritize and integrate the care of chronic respiratory diseases (CRDs) across Europe.
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Industry Calls on Congress to Support SOAR Act
More than a dozen national organizations are pressing Congress to support the Supplemental Oxygen Access Reform (SOAR) Act, which would ensure Medicare patient access to life-saving oxygen therapy.
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Breakthrough Delivers Cystic Fibrosis Gene Therapy to Lungs
A new drug delivery system transports genetic therapies directly to the lungs, opening promising possibilities for patients with conditions like lung cancer and cystic fibrosis.
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NHS England to Offer Alyftrek for Cystic Fibrosis
England’s National Institute for Health and Care Excellence issued a positive final draft recommendation for Vertex Pharma’s Alyftrek CFTR modulator, which will now be available via the National Health Service (NHS).
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European Commission Approves Vertex’s Alyftrek Once-Daily CFTR Modulator
Alyftrek is a triple combination CFTR modulator comprised of deutivacaftor, tezacaftor and vanzacaftor.
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Products 2025: Secretion Clearance & Suction
A closer look at suction and secretion clearance devices from ABM Respiratory, Baxter, Neotech, Philips, Precision Medical, Sentec, Seoil Pacific, and Tactile Medical.
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Nebulized Phage Therapy May Treat Antimicrobial Resistance in CF Patients
Phage therapy—the use of viruses, or phages, to target and kill bacteria—improved lung function and reduced sputum P. aeruginosa in patients with cystic fibrosis.
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RT 2025 April-May: The Digital Edition
RT’s April-May 2025 issue looks at the importance of detecting abnormal lung function in cystic fibrosis patients, skills RTs must possess to successfully intubate a difficult airway, and more.
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Cystic Fibrosis and Abnormal Lung Function
Changes in lung function are of critical importance to patients with cystic fibrosis (CF), as lung function is a key indicator of disease progression and treatment effectiveness.
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7 Recommendations for Cystic Fibrosis Newborn Screening
The CF Foundation’s Newborn Screening Committee developed a consensus guideline with seven recommendations to describe current best practices in newborn screening nationwide.
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CFF Backs Breath Test for P. aeruginosa
Funding from the Cystic Fibrosis Foundation will support development of a breath test to diagnose Pseudomonas aeruginosa infections in CF patients.
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Inequities in Cystic Fibrosis Diagnosis
Researchers say a CF diagnosis within 10 days of birth compared to diagnosis within 6 weeks of birth can produce better height and weight outcomes.
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$2M NIH Grant to Address Pseudomonas-Linked Lung Infections
Funds from NIH will advance ALX1 as a potential treatment in cystic fibrosis and other chronic lung diseases.
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FDA Clears Simeox 200 Airway Clearance Device
The Simeox 200 is intended to promote and improve bronchial drainage by using high-frequency oscillatory vibrations and intermittent negative pressure.
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Virus Infecting Common Bacteria Linked to Accelerated Lung Decline in CF
Cystic fibrosis patients with elevated levels of bacteria infected by Pf phage in their sputum experience a faster decline in lung function.
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