Combination CF Drugs Formoterol + Methacholine May Improve Mucus Clearance
Combining formoterol and methacholine significantly improves mucociliary clearance in animal models of cystic fibrosis, compared to using either drug alone.
Category: Cystic fibrosis
Cystic fibrosis
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Combination CF Drugs Formoterol + Methacholine May Improve Mucus Clearance
Combining formoterol and methacholine significantly improves mucociliary clearance in animal models of cystic fibrosis, compared to using either drug alone.
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Cystic Fibrosis Patient Receives Quadruple Transplant
A 28-year-old cystic fibrosis patient underwent a 36-hour quadruple organ transplant for both lungs, a liver, and a kidney from a single donor.
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COVID-19 Outcomes in Cystic Fibrosis Transplant Patients
New research indicates that baseline lung health is a stronger predictor of SARS-CoV-2 outcomes in cystic fibrosis transplantation patients than the time elapsed since transplantation.
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FDA Approves Expanded Indications for CF Drugs Alyftrek, Trikafta
New label extensions for Alyftrek and Trikafta make approximately 95% of the cystic fibrosis population in the United States eligible for treatment.
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Nanoparticle-based Gene Editing for Cystic Fibrosis
Researchers developed lipid nanoparticles capable of inserting a full healthy CFTR gene into lab-grown human airway cells with severe cystic fibrosis.
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Quantitative Mucin Index: a New Metric to Monitor Lung Health
The Quantitative Mucin Index (MUCQ) of the Lung analyzes sputum and other lung mucus samples to detect airway mucus abnormalities, assess disease risk, and track disease progression in patients over time.
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Reevaluating Salt Intake for Cystic Fibrosis Patients
Researchers assessed salt intake in cystic fibrosis patients undergoing treatment with CFTR modulators, which improve salt conservation and other physiological markers.
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Progress for Cystic Fibrosis Early Diagnosis
A new report shows steady progress in identifying cystic fibrosis earlier, with 67% of CF infants screened in 2024 within the first 28 days of life, compared to 60% in 2014.
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Influenza’s Toll on Cystic Fibrosis Patients
UK patients with cystic fibrosis are being hit hard by a wave of influenza in the country.
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Breakthrough Delivers Cystic Fibrosis Gene Therapy to Lungs
A new drug delivery system transports genetic therapies directly to the lungs, opening promising possibilities for patients with conditions like lung cancer and cystic fibrosis.
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NHS England to Offer Alyftrek for Cystic Fibrosis
England’s National Institute for Health and Care Excellence issued a positive final draft recommendation for Vertex Pharma’s Alyftrek CFTR modulator, which will now be available via the National Health Service (NHS).
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European Commission Approves Vertex’s Alyftrek Once-Daily CFTR Modulator
Alyftrek is a triple combination CFTR modulator comprised of deutivacaftor, tezacaftor and vanzacaftor.
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Products 2025: Secretion Clearance & Suction
A closer look at suction and secretion clearance devices from ABM Respiratory, Baxter, Neotech, Philips, Precision Medical, Sentec, Seoil Pacific, and Tactile Medical.
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Nebulized Phage Therapy May Treat Antimicrobial Resistance in CF Patients
Phage therapy—the use of viruses, or phages, to target and kill bacteria—improved lung function and reduced sputum P. aeruginosa in patients with cystic fibrosis.
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Cystic Fibrosis and Abnormal Lung Function
Changes in lung function are of critical importance to patients with cystic fibrosis (CF), as lung function is a key indicator of disease progression and treatment effectiveness.
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7 Recommendations for Cystic Fibrosis Newborn Screening
The CF Foundation’s Newborn Screening Committee developed a consensus guideline with seven recommendations to describe current best practices in newborn screening nationwide.
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CFF Backs Breath Test for P. aeruginosa
Funding from the Cystic Fibrosis Foundation will support development of a breath test to diagnose Pseudomonas aeruginosa infections in CF patients.
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Inequities in Cystic Fibrosis Diagnosis
Researchers say a CF diagnosis within 10 days of birth compared to diagnosis within 6 weeks of birth can produce better height and weight outcomes.
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Virus Infecting Common Bacteria Linked to Accelerated Lung Decline in CF
Cystic fibrosis patients with elevated levels of bacteria infected by Pf phage in their sputum experience a faster decline in lung function.
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FDA Approves Alyftrek CFTR Modulator for Cystic Fibrosis
The FDA approved Alyftrek, a once-daily triple combo CFTR modulator, for certain cystic fibrosis patients aged 6 and older.
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CF Foundation Invests $15M in ReCode to Develop Gene Editing Therapy
The Cystic Fibrosis Foundation is funding the development of a gene editing therapy that is designed to use ReCode’s tissue-specific delivery vehicle to transport gene editing cargo to the lung cells in people with cystic fibrosis.
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How to Help Patients Adhere to Airway Clearance Therapy at Home
Adherence to airway clearance therapy in the home is crucial for managing chronic lung conditions, but challenges like time constraints and lack of perceived benefit can hinder patient compliance. Experts offer strategies and new technologies to help improve patients’ adherence.
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FDA Awards Rare Pediatric Disease Designation to Investigational Cystic Fibrosis Treatment
ETD001 aims to improve lung function by targeting mucus clearance in patients with high unmet medical needs.
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FDA Greenlights Phase 2 Study of Inhaled mRNA Treatment for Cystic Fibrosis
The phase 2 study will evaluate the safety and efficacy of ARCT-032, an inhaled mRNA therapy for cystic fibrosis patients, which previously received Orphan Drug Designation.
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