Phage Therapy Investigated for Cystic Fibrosis
Enrollment has begun in an early-stage clinical trial evaluating phage therapy (bacteriophage) in adults with cystic fibrosis who carry Pseudomonas aeruginosa in their lungs.
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Phage Therapy Investigated for Cystic Fibrosis
Enrollment has begun in an early-stage clinical trial evaluating phage therapy (bacteriophage) in adults with cystic fibrosis who carry Pseudomonas aeruginosa in their lungs.
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Cystic Fibrosis: Long-Term Antibiotics Not Needed in Patients Without Chronic P Aeruginosa
Outcomes don’t improve in cystic fibrosis patients given long-term inhaled antibiotics who do not have chronic Pseudomonas aeruginosa, a new study found.
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Pseudomonas Superbug Develops Fast Resistance to ‘Last Resort’ Antibiotic
Mutations in a gene known as pmrB allow the bacteria Pseudomonas to evolve resistance to Colistin, a “last resort” antibiotic.
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P. aeruginosa and Fluconazole Work Together to Fight Candida Albicans
A study of fungal lung infections found that P. aeruginosa works with fluconazole to eliminate drug tolerance and clear Candida albicans infections.
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Antibiotic Overuse Likely in Patients with Severe COVID-19 Pneumonia
Only 21% of patients with severe pneumonia caused by SARS-CoV-2 have a documented bacterial superinfection at the time of intubation, resulting in potential overuse of antibiotics.
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How Bacteria Can Defeat Drugs That Fight Cystic Fibrosis
Scientists have conducted new research into how bacteria defeat antibiotics in infections that are commonly seen in cystic fibrosis patients.
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Mechanics of Mucus in Cystic Fibrosis Patients
A mutation in P. aeruginosa creates a protective film of mucus around the bacteria thereby forming a more hydrated and slimy biofilm in the mucus.
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Protein at the Root of Cystic Fibrosis Infections
Swiss researchers highlight how the protein Vav3 creates bacterial docking stations to facilitate lung infections in cystic fibrosis.
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Mucus Uses Glycans to ‘Disarm’ Bacteria
Mucus uses glycans in concert with mucins to “regulate” the behavior of bacteria like Pseudomonas aeruginosa, preventing bacterial communication and biofilm formation, according to MIT research.
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Bronchiectasis Patients Over Age 55 at Greater Risk of P. aeruginosa Infections
Risk of lung colonization by pseudomonas aeruginosa is greater for bronchiectasis patients age 55 and older, according to research published in EJCMID.
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Decrease in Cystic Fibrosis LRTIs Due to P. Aeruginosa
New research points to significant decreases in lower airway infections due to Pseudomonas aeruginosa, Staphylococcus aureus and Haemophilus influenzae among young children with cystic fibrosis.
Read MoreAzithromycin Added to Standard Therapy for P. Aeruginosa Infection Reduces Lung Exacerbations
Adding azithromycin to the standard antibiotic treatment for early Pseudomonas aeruginosa infections is associated with fewer pulmonary exacerbations in children with cystic fibrosis, results from a Phase 3 trial show. Trial...
Read MoreAztreonam Safe, Effective for Cystic Fibrosis Patients with PALS
A phase 3 clinical trial of inhalable Aztreonam (AZLI) in children up to 12 with CF and chronic P. aeruginosa infection in the lower airways (PALS) reported no safety issues, according to Gilead Sciences Inc. The results mean that AZLI could become a viable treatment for infection in CF patients in the near future.
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Fighting Waterborne Pathogens To Protect Ventilated Patients
In addition to the constant threat of ventilator-associated pneumonia, ventilated patients also face dangers from other less common hospital-acquired infections, including waterborne pathogens that can occur during humidification.
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Natural Antimicrobial Exacerbates Infection In Cystic Fibrosis
An antimicrobial peptide produced by human immune cells can promote mutations in P. aeruginosa bacterium, a common cause of death in cystic fibrosis patients.
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P. aeruginosa Converts Protein into Virulence Factor
Scientists have long thought Pseudomonas aeruginosa mostly uses protein inside the cell, but new studies show that as a virulence factor, it could represent a vulnerability for the bacterium.
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How the Loss of an Inflammatory Protein Impacts Lung Infections
Examination of the lungs of infected mice showed that neutrophils lacking TREM-1 were unable to migrate to the site of infection.
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Attacking Cystic Fibrosis on Many Fronts
Cystic fibrosis can be a devastating, even fatal, disease; but proper diagnosis and new treatments, coupled with breakthroughs in gene replacement therapy, offer improved outcomes.
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