Younger Lung Cancer Patients Have Treatable Genetic Changes
A study of more than 14,000 lung cancer patients suggests age influences tumor biology and the availability of targeted therapy options.
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Younger Lung Cancer Patients Have Treatable Genetic Changes
A study of more than 14,000 lung cancer patients suggests age influences tumor biology and the availability of targeted therapy options.
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New Computational Tool Identifies Previously Hidden Asthma Genes
Researchers used a new mapping method to find 21 genes that drive asthma biology, potentially revealing new targets for drug development.
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New DNA Markers May Predict Lung Cancer Recurrence
Specific circular DNA features found in blood and tissue could help clinicians identify patients at high risk for recurrence after surgery.
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Intelligenome, Cornell Partner on Portable TB Diagnostic
The collaboration will focus on a point-of-care testing platform designed to detect tuberculosis from respiratory and blood samples.
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CHLA Joins Sickle Cell Study on Gene Editing Method
Children’s Hospital Los Angeles joined a trial to investigate nula-cel, a gene-editing therapy designed to correct the sickle cell disease genetic mutation.
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First US Toddler Diagnosed With Rare Lung Disease
A two-year-old Indiana child is the first in the United States to be diagnosed with Rajab interstitial lung disease with brain calcifications, a rare genetic disease with only 10 known cases worldwide.
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Genetic Scoring Tool May Improve IPF Diagnosis
A study of more than 570,000 people validates a polygenic risk score to identify idiopathic pulmonary fibrosis patients at risk for severe outcomes or death.
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Genetic and Telomere Assessments Improved Pulmonary Fibrosis Care
Integrating genetic and telomere assessments into clinical care helps physicians refine diagnoses and adjust pulmonary fibrosis treatment plans.
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How Genetic Mutations Cause Primary Ciliary Dyskinesia
An imaging study reveals how gene mutations impair airway clearance and lead to primary ciliary dyskinesia (PCD).
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Pediatric Interstitial Lung Disease Tied to Novel Disorder with Genetic Causes
Researchers linked loss-of-function variants in the TMEM63B gene to a novel disorder causing interstitial lung disease in some pediatric patients.
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Sleep, Exercise Mitigate Cardiovascular Risk From Blood Mutations
Research indicates that healthy lifestyle habits can repress the inflammatory effects of age-related genetic mutations in white blood cells.
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Why Some Alpha-1 Patients Develop Liver Disease
A newly discovered biological process protects liver cells from protein buildup in patients with alpha-1-antitrypsin deficiency.
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New CRISPR Can Shred Infected Cells’ DNA
Researchers have developed a new form of CRISPR technology that destroys harmful cells instead of editing their genes, while leaving healthy tissue untouched.
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Researchers ID Genetic Target for Aggressive Lung Cancers
UCLA study finds that small cell neuroendocrine tumors depend on a specific protein to grow, offering a potential path for new treatments.
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Nanoparticle-based Gene Editing for Cystic Fibrosis
Researchers developed lipid nanoparticles capable of inserting a full healthy CFTR gene into lab-grown human airway cells with severe cystic fibrosis.
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Reevaluating Salt Intake for Cystic Fibrosis Patients
Researchers assessed salt intake in cystic fibrosis patients undergoing treatment with CFTR modulators, which improve salt conservation and other physiological markers.
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PCD Center Adds LRS Machine for Genetic Testing
Recent funding has allowed Children’s Hospital of Chicago’s Primary Ciliary Dyskinesia Center to purchase its first Long Read Sequencing (LRS) machine to aid PCD genetic testing.
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Progress for Cystic Fibrosis Early Diagnosis
A new report shows steady progress in identifying cystic fibrosis earlier, with 67% of CF infants screened in 2024 within the first 28 days of life, compared to 60% in 2014.
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Genetic Drivers of Long COVID
Scientists identified key genetic drivers behind long COVID, revealing why some people experience symptoms long after initial infection.
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Positive Casgevy Data for Sickle Cell Disease in Younger Children
New clinical data for Casgevy in younger SCD/TDT patients age 5-11 show efficacy and safety consistent with older populations.
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Potential Gene-based Treatment for Sepsis, Lung Injury
Findings suggest that the endothelial gene ALOX15 gene protects against sepsis-induced lung injury.
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Positive Data for efdoralprin alfa in Alpha-1 Emphysema
Sanofi’s efdoralprin alfa met all primary and key secondary endpoints in a phase 2 clinical trial for adults with alpha-1 antitrypsin deficiency emphysema.
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Breakthrough Delivers Cystic Fibrosis Gene Therapy to Lungs
A new drug delivery system transports genetic therapies directly to the lungs, opening promising possibilities for patients with conditions like lung cancer and cystic fibrosis.
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Searching for Genetic Causes of Asthma
New research used genome wide association studies (GWAS) to identify significant differences in the sets of genes that could be linked to adult-onset and childhood-onset asthma.
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