Researchers are developing liquid nanoparticles to bypass the barriers posed by thick mucus and frequent infections in cystic fibrosis lungs and prevent antimicrobial resistance.

RT’s Three Key Takeaways

  1. University of South Australia researchers, backed by a $500,000 grant from Brandon BioCatalyst’s CUREator incubator, are developing liquid crystal nanoparticle-formulated antibiotics to target challenging lung infections in cystic fibrosis patients.
  2. This patented platform technology aims to enhance antibiotic efficacy and tackle antimicrobial resistance by improving drug delivery to the lungs, overcoming barriers posed by thick mucus and frequent infections.
  3. Promising preclinical studies have shown the effectiveness of liquid crystal nanoparticles against various infections, leading to the development of a nebulization approach for direct lung delivery, offering hope for significant improvements in cystic fibrosis and other lung infection treatments.

Cystic fibrosis is the most common, life-limiting genetic condition in Australia. It affects the lungs, digestive system, and reproductive system, producing excess mucus, infections, and blockages.

Now, thanks to a $500,000 grant from Brandon BioCatalyst’s CUREator incubator, through their CSIRO-funded Minimizing Antimicrobial Resistance Stream, University of South Australia researchers are advancing the development of liquid crystal nanoparticle-formulated antibiotics to more accurately target and eliminate difficult-to-cure lung infections in people with cystic fibrosis.

Looking for New Therapies

The study will use a patent-protected platform technology, invented by UniSA’s Centre for Pharmaceutical Innovation to establish new therapies for cystic fibrosis sufferers. UniSA will also work with the Cystic Fibrosis Airways Research Group at the Women’s and Children’s Hospital to advance the platform.

In Australia more than 3,600 people live with cystic fibrosis with one in every 2,500 babies born with the disease.

Lead investigator UniSA’s Professor Clive Prestidge says that liquid crystal nanoparticles present a unique encapsulation and delivery system to improve the efficacy of antibiotics and overcome issues of antimicrobial resistance.

“When a person has cystic fibrosis, their body produces a sticky, thick mucus in the lungs which is prone to infection,” Prof Prestidge says.

“Bacterial lung infections often require antibiotics, but with frequent infections and regular ineffective antibiotic use, bacteria are becoming resistant to treatments; the looming antimicrobial resistance (AMR) pandemic is a major threat to human health.

“When there is infection and blockages in the lungs, it’s particularly hard for traditional antibiotics to reach their target. That’s where liquid crystal nanoparticles can help.

“By overcoming the processes that cause drug resistance and uncontrollable infection, this unique delivery approach can better target sites in the body where conventional antibiotic therapies cannot penetrate.”

Promising Preclinical Results

Postdoctoral researcher and team member, UniSA’s Dr Santhni Subramaniam says preclinical studies have already demonstrated excellent performance against such infections. 

“Whether it’s bacteria in urinary tract infections, bone infections or bacterial biofilms found in tissue wounds, sinuses, and lung infections, preclinical trials of liquid crystal nanoparticles have delivered very positive results,” Dr Subramaniam says.

“We are now positioned to advance a nebulization approach for direct lung delivery.

“This is an exciting new technology that we hope will deliver significant improvement in people struggling with cystic fibrosis and other lung infections.”