A population-based, case-crossover study published in JAMA Psychiatry supported the suspected connection between antipsychotic medication and respiratory distress in patients with COPD. 

“The results of this study indicated a life-threatening adverse respiratory effect of antipsychotic treatment, which has been described previously only in case reports,” they wrote.

Antipsychotics have been linked to acute respiratory failure in case reports, but population-level data are lacking, the researchers explained. Also, this effect is of particular concern among COPD patients, who are already prone to respiratory failure and are commonly treated with antipsychotics.

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