Identifying and treating people with previously undiagnosed asthma or COPD led to improved respiratory symptoms, quality of life, and reduced healthcare visits in the year after diagnosis.


RT’s Three Key Takeaways:

  1. Researchers called random phone numbers across Canada to identify people with respiratory symptoms like shortness of breath, wheezing, or prolonged cough who were likely to have undiagnosed asthma or COPD. Through spirometry testing, 595 individuals were newly diagnosed with one of the conditions.
  2. Participants randomized to receive treatment from a lung specialist and asthma/COPD educator, including inhalers, action plans, and lifestyle counseling, averaged just 0.53 healthcare visits per year for respiratory symptoms after diagnosis compared to 1.12 visits for those receiving usual care.
  3. Proper treatment following diagnosis led to significant improvements in respiratory health and quality of life scores for both groups, demonstrating that diagnosing hidden asthma and COPD cases, even through primary care, allows effective disease management.

Finding and treating people with undiagnosed asthma or chronic obstructive pulmonary disease (COPD) improved their health and reduced their healthcare visits for respiratory symptoms in the year after diagnosis, according to a clinical trial published in the New England Journal of Medicine.

“It’s estimated that 70% of people with asthma or COPD go undiagnosed,” says study lead Shawn Aaron, MD, MSc, FRCPC, a senior scientist and lung specialist at The Ottawa Hospital and professor at the University of Ottawa, in a release. “This is the first study to prove that treating those people makes a real difference to their health and quality of life.”

How Did the Research Team Find Undiagnosed Cases?

To find people with undiagnosed asthma and COPD, the research team called random phone numbers at 17 study sites across Canada from 2017 to 2023. An automated call asked whether any adults in the household had unexplained shortness of breath, wheezing, prolonged cough, or were coughing up mucus in the past six months.

The 26,905 people who reported these symptoms completed questionnaires. Those most likely to have asthma or COPD did a spirometry breathing test, the gold standard for diagnosis.

A total of 595 people were diagnosed with either asthma or COPD, and 508 agreed to participate in a randomized controlled trial to compare different types of care.

Half the people in the trial were randomly assigned to usual care (care provided by their primary care provider or a walk-in-clinic), while the other half were treated by a lung specialist and asthma/COPD educator (a specially-trained nurse or respiratory therapist).

Individuals treated by a lung specialist and educator were prescribed inhalers to treat their asthma or COPD and were taught how to use them. Some were given action plans to help them manage disease flare-ups themselves. They were provided with smoking cessation treatment, exercise and weight counseling, and pneumonia and flu vaccines if appropriate.

Ninety-two percent of patients seen by a lung specialist and asthma/COPD educator started new medications for asthma or COPD, compared to 60% of patients who received usual care.

Treating Undiagnosed Asthma, COPD Leads to Fewer Healthcare Visits

The researchers found that patients seen by a lung specialist and asthma/COPD educator averaged 0.53 healthcare visits per year for respiratory symptoms in the year after diagnosis, compared to 1.12 visits in the usual care group.

In addition, patients seen by a lung specialist and asthma/COPD educator saw their average score on the St. George’s Respiratory Questionnaire rise by 10.2 points, compared to 6.8 points for the usual care group. A four-point rise means an improvement in health and quality of life.

“In the real world, not everyone can see a lung specialist,” says Aaron in a release. “The good news is that as long as a patient gets diagnosed and treated, their symptoms will improve. The people in our study who went to primary care providers and walk-in clinics had great outcomes, and those who went to a lung specialist and asthma/COPD educator had excellent outcomes.”

‘Asthma Diagnosis Makes a Big Difference,’ Says Study Participant

Jazzminn Hein was 24 years old and had recently given birth to her first child when she got the call inviting her to join the study. Carrying a few loads of laundry up the stairs or talking on the phone for 10 minutes would leave her breathless. She didn’t see the downside to getting a breathing test.

“For years I told doctors about this elephant on my chest and struggling to breathe. They said it was my anxiety, that I was having panic attacks,” says Hein in a release.

But it wasn’t panic attacks. It was asthma. Asthma that she’d likely had since grade school. A daily inhaler turned her symptoms around.

“The asthma diagnosis makes a big difference,” she says in a release. “Your muscles need oxygen, and when you can’t breathe properly it makes you sore and tired all the time. I’ve noticed an increase in energy. I have two small kids now, and I can keep up with them. I sleep better because I used to regularly wake up struggling to breathe.”

Asthma affects 8% of Canadian adults and can develop at any age, while COPD affects 8% of Canadians over the age of 60.

“If you have breathing symptoms like mine, go to your doctor or a walk-in clinic and ask for a spirometry test,” says Hein in a release. “The worst that can happen is that you’ll have wasted your time. But if you do have a respiratory disease and get it properly treated, you’ll be able to do things you hadn’t realized you missed.”

Aaron agrees with Hein. He thinks the best way to catch more cases of undiagnosed asthma and COPD is for patients to advocate for themselves. His past research found that even early stages of these diseases are linked with worse quality of life, greater healthcare use, and decreased work productivity.

“Many people know to ask for breast cancer and colon cancer tests when they see certain signs. Ideally, they’d ask for a spirometry test when they notice symptoms of chronic respiratory diseases,” says Aaron in a release. “People don’t have to put up with these breathing problems when there is effective treatment available.”

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