Researchers from Yale University have begun to connect the same genes—including ADAM33 and ORMDL3—to asthma, a major step forward in identifying the origin of the disease.

Pinpointing the genes most responsible for asthma has proven to be a daunting task with too many genetic possibilities to sift through.

Modern researchers have postulated associations between asthma and more than 400 genes, but to discover the ailment’s foundations they must identify both the causative genes and the specific mutations within them that point to the disease.

The genes that may impact the risk for asthma seem to connect or interact in a number of combination that are not necessarily consistent, where the combination that leads to asthma differs in each individual.