The Cleveland Clinic just announced its top 10 medical innovations for 2015 – a listing of the most gamechanging new health techs.

To receive consideration, nominated technologies must (a) have significant clinical impact and patient benefit in comparison to current practices, (b) have a high probability of commercial success, (c) be available on the market in 2015, and (d) have significant human interest in its application or benefits.

The list includes pirfenidone and nintedanib (#8), the first two drugs approved by the FDA to treat idiopathic pulmonary fibrosis, which afflicts some 80,000 Americans.

1. Mobile Stroke Unit

2. Dengue Fever Vaccine

3. Cost-effective, Fast, Painless Blood-Testing

4. PCSK9 Inhibitors for Cholesterol Reduction Effective

5. Antibody-Drug Conjugates Chemotherapy

6. Checkpoint Inhibitors Cancer

7. Leadless Cardiac Pacemaker

8. New Drugs for Idiopathic Pulmonary Fibrosis 

9. Single-Dose Intra-Operative Radiation Therapy for Breast Cancer

10. New Drug for Heart Failure Angiotensin-receptor neprilysin inhibitor (ARNI)