Research shows children attending daycare had clinically significant lower IgE levels and lower rates of food and perennial aero-allergen sensitization.
RT’s Three Key Takeaways:
- Protective Effect of Daycare – Children who attended daycare in their first year of life showed lower total IgE levels and a decreased occurrence of food and perennial aero-allergen sensitization.
- Statistical Significance – Daycare attendance was associated with a 44% reduction in total IgE levels and a 44% lower likelihood of food sensitization and a 43% lower likelihood of perennial aeroallergen sensitization.
- Impact on Asthma and Allergies – The study suggests that early-life daycare exposure might play a role in reducing the risk of asthma and allergic diseases, especially in populations like Puerto Rican children, who are disproportionately affected by these conditions.
Daycare attendance is protective against food and perennial aero-allergen sensitization according to research presented at AAAAI 2024.
The impact of early-life daycare attendance on the development of asthma and allergic diseases could significantly influence later childhood health, the study concluded. To explore the effects of daycare attendance, researchers collected demographic and clinical measures from consenting mothers and their children in the Puerto Rican Infant Metagenomic and Epidemiologic Study of Respiratory Outcomes (PRIMERO) cohort at Hospital Interamericano de Medicina Avanzada-San Pablo, Puerto Rico.
“Puerto Rican children bear a disproportionate burden of asthma and allergies, compounded by an overrepresentation of the socioeconomic and environmental determinants associated with these conditions,” says primary author Jonathan Witonsky, MD, MAS, Assistant Professor in the Pediatric Division of Allergy, Immunology, and Bone Marrow Transplant at the University of California, San Francisco. “Findings from the PRIMERO birth cohort offer crucial insights into the impact of early-life exposures, including daycare attendance, on the development of childhood asthma and allergic diseases.”
A total of 2,100 children are enrolled in the ongoing study with blood samples collected for total IgE and allergen-specific IgE testing during the 2-year visit. Researchers used regression analyses to explore the association of daycare attendance in the first year of life with total IgE levels and allergen sensitization. Daycare attendance status, total IgE levels and allergen-specific IgE measurements were available for 559 children, of which 22% attended daycare. Daycare attendance in the first year of life was associated with lower IgE levels (coefficient: -0.41 log IU/mL, P < 0.01) and decreased occurrence of food (OR: 0.56, 95% CI: 0.36 to 0.85) and perennial aeroallergen (OR: 0.57, 95% CI: 0.34 to 0.93) sensitization.
The findings suggest that early-life exposures in daycare may be protective against allergen sensitization. This is an important step in understanding prevention and potentially lowering the risk of asthma and allergic diseases in children.
