Many children with recurrent wheezing have undetected lung infections that may be more effectively treated with antivirals instead of commonly prescribed steroids.
RT’s Three Key Takeaways:
- Prevalence of Silent Infections: The study found that 22% of children with recurrent wheezing have undetected lung infections, which do not present typical cold symptoms and are often overlooked.
- Treatment Implications: The research suggests that these silent lung infections may be better treated with antiviral medications like azithromycin, rather than the commonly prescribed corticosteroids, which can have significant side effects and may not address the root cause.
- Need for Revised Protocols: The findings indicate a need for doctors to reassess the use of steroids in treating recurrent wheezing in children and consider antiviral treatments to address underlying infections, potentially reducing long-term health risks.
Nearly a quarter of children with recurrent wheezing have “silent” lung infections that would be better treated with antiviral medications than commonly prescribed steroids that can carry lifelong side effects, new research from the University of Virginia School of Medicine reveals.
Pediatric pulmonologist W. Gerald Teague, MD, was inspired to investigate after noting large numbers of children with stubborn wheezing cases referred from community providers and through the UVA Health Emergency Department.
Knowing that rhinoviruses—the main cause of the common cold—can trigger wheezing episodes, Teague wanted to see if there was a link between the recurrent wheezing and “indolent” lung infections—infections that can carry no symptoms and persist for long periods.
Screening Children with Wheezing
After screening more than 800 children and teens with severe wheezing, he and his collaborators determined that 22% had undetected lung infections that did not display typical cold symptoms. These infections do not respond to corticosteroids commonly used to treat wheezing; in fact, the researchers found that higher doses of the steroids may put children at increased risk for lingering lung inflammation, in addition to known side effects such as irritable behavior, reduced bone density and suppressed growth.
“While steroids can help some children with wheeze, many children in the study showed no patterns of inflammation that would improve with steroids,” says Teague, a clinician-scientist at the School of Medicine’s Child Health Research Center, in a release. “I advise the parents of my patients that wheeze episodes that are triggered by colds should be treated with anti-inflammatory medications that build immunity to viruses, such as azithromycin. They look surprised that we would use an antibiotic for a viral infection, but, in fact, azithromycin bolsters the immune response to viruses in a positive way.”
Underlying Causes of Recurrent Wheezing
Teague and his collaborators are uncertain why the children have been unable to shake off silent lung viral infections. While rhinoviruses were by far the most common infection identified, Teague and his team detected other unresolved respiratory infections as well.
The scientists suspect something may be going awry with the mucosal immune cells in the children’s lungs, making them unable to fight off these viruses. Notably, the problem seems to primarily affect very young children and becomes less common by school age, the researchers found.
Further research is needed, the scientists say, to better understand the cause of this immune malfunction and find ways to remedy it. In the meantime, doctors should rethink how they treat recurrent wheezing, Teague says. Before prescribing powerful corticosteroids, doctors need to ensure that children have inflammation that will respond to the steroids rather than lung infections that would be better treated with antivirals.
“Viral infections are the most important trigger of acute wheeze episodes in children and, in some cases, lead to respiratory distress and hospital care. We hope this discovery will stimulate further work in the treatment of recurrent wheeze and viral infections in children,” Teague says in a release. “The field has to get to away from overuse of potentially toxic steroids for the treatment of acute wheeze to include novel therapies which target specific patterns of inflammation.”
Based on the findings, Teague plans to study whether this type of faulty immune response may also be a risk factor for children developing asthma.
The study was published in the Journal of Allergy and Clinical Immunology.
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