Treating invasive fungal infections with voriconazole led to hallucinations and other central nervous system side effects according to research at IDWeek 2018. Discontinuing voriconazole frequently reduced these symptoms.

Researchers screened 341 patients who received voriconazole therapy in the form of at least 1 voriconazole serum concentration measurement during their stay.

Among the 341 patients screened, 20 reported experiencing central nervous system symptoms that correlated with voriconazole therapy initiation; 11 patients who experienced symptoms also received concomitant opioid treatment, which has known side effects of visual hallucinations.