The results of a clinical trial show no correlation between adenotonsillectomies and undesirable weight gain in children.
Summary: A Michigan Medicine-led clinical trial found no correlation between adenotonsillectomy, a surgical procedure for children with mild sleep-disordered breathing, and undesirable weight gain, contradicting a common assumption. While the procedure improved certain outcomes like symptoms and quality of life, the study concluded that weight gain trends in children were independent of the surgery, driven by natural growth trajectories or underlying conditions.
Key Takeaways:
- No Link to Weight Gain: The trial found no significant association between adenotonsillectomy and undesirable weight gain in children with mild sleep-disordered breathing.
- Weight Gain Misconceptions: Past perceptions of surgery-related weight gain were likely influenced by “catch-up” growth in underweight children and natural weight trajectories in overweight children.
- Focus on Healthy Habits: Nearly a third of participants experienced weight gain unrelated to the surgery, highlighting an opportunity for clinicians to encourage healthy weight management in children with mild sleep-disordered breathing.
Adenotonsillectomy for children with mild sleep-disordered breathing is not linked to undesirable weight gain, according to a Michigan Medicine-led trial.
The paper appears in JAMA Otolaryngology-Head & Neck Surgery.
Adenotonsillectomy has a high success rate at improving symptoms of mild sleep-disordered breathing in children. Mild sleep-disordered breathing occurs when children have obstructive sleep apnea symptoms but no clear obstructive sleep apnea on sleep lab testing.
Study Design and Findings
The Pediatric Adenotonsillectomy Trial for Snoring included 458 children with mild sleep-disordered breathing, randomized into two groups: those who underwent adenotonsillectomy and those who received “watchful waiting with supportive care.”
The overall results of the trial showed that adenotonsillectomy didn’t result in a statistically significant improvement in primary neurodevelopmental outcomes but did result in improvement in certain secondary outcomes, such as symptoms, blood pressure, and quality of life. This latest paper uses data from the trial to test the assertion that unwanted weight gain is a potential side effect of the procedure.
“For many years, tonsillectomy causing weight gain in kids was a common assumption based on early studies with little control data,” says Erin Kirkham, MD, MPH, FACS, pediatric otolaryngologist at U-M’s CS Mott Children’s Hospital and lead author on the study, in a release. “It turns out kids who are overweight tend to gain more weight over time regardless of whether or not they’ve had surgery for sleep apnea. Previously, we were seeing a natural trajectory of weight gain—that was going to happen anyway—and attributing it to surgery.”
Weight and Sleep-Disordered Breathing
Weight and sleep-disordered breathing in children are interrelated. Children with obesity are more likely than other children to develop symptoms.
In addition, underweight patients who are failing to thrive due to their sleep-disordered breathing can experience a desired weight gain after adenotonsillectomy.
Researchers believe that such “catch up” weight gain among children in past studies also contributed to the perception that adenotonsillectomies could cause undesirable weight gain.
Grouping underweight children in with normal and overweight children made it seem as if the group as a whole gained weight after surgery, researchers note.
Additional Research Insights
A previous paper from the same research team using data from a different randomized trial involving children with obstructive sleep apnea, “Weight gain in children after adenotonsillectomy: undesirable weight gain or catch-up growth?” appeared in Sleep Medicine in 2021 and concluded, “Adenotonsillectomy may not be an independent risk factor for undesirable weight gain in children.”
For the Pediatric Adenotonsillectomy Trial for Snoring trial, researchers defined undesirable weight gain in two ways: underweight or normal-weight children who became overweight after 12 months, and already overweight children who continued to gain weight in the same span.
Undesirable weight gain occurred after 12 months in 32% of cases from the adenotonsillectomy group (120 children), versus 27% of the watchful waiting group (101 children). A regression analysis did not find a significant association between adenotonsillectomy and undesirable weight gain.
Clinical Implications
“The upshot is that if you’re a sleep specialist—or an otolaryngologist considering taking out a child’s tonsils—you don’t have to worry families as much by saying, ‘There’s an obesity epidemic, and if you choose surgery, it could increase the risk of obesity for your child,’” says Ronald D. Chervin, MD, MS, Michael S. Aldrich Collegiate Professor of Sleep Medicine at U-M, director of its Sleep Disorders Center and senior author on the paper, in a release.
The authors note, however, that nearly a third of the participants did experience unwanted weight gain, even if adenotonsillectomy was not the cause.
They emphasize that there’s an opportunity for clinicians to encourage healthy weight management when they see overweight children with mild sleep-disordered breathing.
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