How to Treat Severe Infections in the ICU is a special series with a variety of features, including diagnostics and antibiotic resistance in the ICU setting.

The treatment of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), in critically ill patients is explored in a review by Marin Kollef and colleagues. The rise in infectious caused by these agents is discussed, alongside the need for prompt and effective treatment with appropriate antibiotics.