According to research in Infection Control & Hospital Epidemiology, fluoroquinolone resistance had a greater affect on hospital mortality than other phenotypic-resistance profiles.

Researchers analyzed the correlation between fluoroquinolone resistance (FR), extended-spectrum cephalosporin resistance (ESCR) and mortality among patients with hospital-onset GNR bacteremia.

According to the study, from 2003 to 2013, there were 6,860 patients with E. coli or Klebsiella species hospital-onset bacteremia: 4,813 with no resistance identified, 1,029 with ESCR, 202 with FR and 816 with both. Suzuki and colleagues included 19,664 patient-level matched, uninfected controls in the analysis.

Results showed that all four groups had higher 30-day mortality rates than uninfected patients.