Development of pulmonary arterial hypertension (PAH) may be related to increased production of Nestin protein in the pulmonary vasculature, a Plos One study reports.

Results showed that Nestin was in general more abundant in PAH samples. In particular, Nestin was found to be mainly present in endothelial cells close to vascular lesions.

This finding was further confirmed when the team analyzed Nestin levels in the lungs and pulmonary arteries of mice with induced severe pulmonary hypertension.