Alpha-1 Antitrypsin Deficiency Drug Enters Ph3 Trial
Grifols enrolled the first patient in its Phase 3 SWIFT-SC clinical trial to evaluate its subcutaneous Alpha1-Proteinase Inhibitor for the treatment of alpha1-antitrypsin (AAT) deficiency.
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Alpha-1 Antitrypsin Deficiency Drug Enters Ph3 Trial
Grifols enrolled the first patient in its Phase 3 SWIFT-SC clinical trial to evaluate its subcutaneous Alpha1-Proteinase Inhibitor for the treatment of alpha1-antitrypsin (AAT) deficiency.
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Alpha-1 Drug Candidate Superior to Standard Care
Phase 2 data for efdoralprin alfa demonstrate the recombinant protein maintains normal protein levels with less frequent dosing than current standards of care for patients with alpha-1 antitrypsin deficiency (AATD)-related emphysema.
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Why Some Alpha-1 Patients Develop Liver Disease
A newly discovered biological process protects liver cells from protein buildup in patients with alpha-1-antitrypsin deficiency.
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Positive Data for efdoralprin alfa in Alpha-1 Emphysema
Sanofi’s efdoralprin alfa met all primary and key secondary endpoints in a phase 2 clinical trial for adults with alpha-1 antitrypsin deficiency emphysema.
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Combining Alpha-1 Assays May Improve Diagnosis
Combining Alpha-1 antitrypsin deficiency (AAT/AATD) assays allowed a multitiered AATD testing algorithm to improve diagnosis.
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Bronchiectasis and NTM Research Registry Data Presented at ERS 2025
The European Respiratory Society Congress featured two abstracts using data from the Bronchiectasis and NTM Research Registry.
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Company to Deploy Gene Editing for Alpha-1 Disease
Prime Medical will use its gene editing platform to correct the gene mutations that lead to alpha-1 antitrypsin deficiency (AATD) lung disease and liver disease.
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Lung Disease Tied to Higher Heart Disease Risk Regardless of Risk Factors
Despite certain study participants having lower risk factors associated with developing cardiovascular disease, including being younger and a higher proportion who had never smoked, 12.7% of participants developed cardiovascular disease after four years of follow-up.
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Women at Greater Risk of Developing COPD
The risk of developing COPD could be 50% greater for women as it is for men, according to a new diagnostic method utilized by researchers from Lund University Sweden.
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Raising Awareness of Alpha-1
Compared to COPD, asthma, or cystic fibrosis, Alpha-1 antitrypsin deficiency lung disease is not well known, but dedicated researchers and RTs continue to support patients and work towards finding new treatment options.
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Researchers Successfully Transfer Alpha-1 Antitripsin into Mice Lungs
Individuals with single-gene mutations that decrease levels of the protein alpha-1 antitrypsin are at high risk for emphysema at a young age. Researchers have attained sustained in vivo expression of normal human alpha-1 antitripsin—and at levels that improved emphysema in mice.
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Alpha-1 Finds a Voice
Thanks to the Alpha-1 Foundation, many COPD patients with alpha-1 antitrypsin deficiency have been properly diagnosed and treated, but the work is far from over.
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US News & World Report Names Best Respiratory Hospital in the Nation
For the 12th year in a row, US News & World Report named National Jewish Health, Denver, the best respiratory hospital in the nation.
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More Alpha-1 Antitrypsin Testing Needed for COPD/Asthma Patients
A higher than expected number of COPD and asthma patients had abnormally low levels of alpha-1 antitrypsin.
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Industry Insider: Alpha-1 and Zemaira
RT spoke with ZLB Behring, the company that manufactures the alpha-1 therapy Zemaira, to gain a better understanding of alpha-1 and the treatments available.
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Air Travel for Oxygen Patients Is Complicated
Air travel is complicated for oxygen-dependent people, involving fees that can double the cost of the ticket and periods of time without access to oxygen. Patient and professional advocacy efforts might help.
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