The Centers for Disease Control and Prevention (CDC) is calling 2014 an “unprecedented” year for public health challenges, citing the Ebola epidemic and a rise in other communicable diseases.

The agency’s response to Ebola is the largest in its history, involving 170 field staff and 700 others working on anti-Ebola projects, CDC officials said in a report on the year’s activities. At the same time, the agency is battling other emerging threats such as enterovirus D-68, Middle East Respiratory Syndrome and healthcare-related infections strengthened by antibiotic resistance.