Novartis AG has announced positive results from Phase III FLAME trial examining the rate of COPD exacerbations.

In the FLAME study, once-daily Ultibro Breezhaler met primary endpoint and demonstrated superiority to Seretide in reducing COPD exacerbations during 52 weeks of treatment.

FLAME was a randomized, double-blind, parallel-group, non-inferiority, active-controlled 52-week study involving 3,362 COPD patients and conducted at 356 sites across 43 countries.

The first large-scale study confirmes that Ultibro Breezhaler is an effective steroid-free option that both reduces exacerbations and improves lung function in COPD patients with one or more exacerbations in the past year, compared to Seretide, the company said.

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