The type of e-cigarette flavor along with the presence of nicotine had variable effects on airway inflammation and hyperresponsiveness, according to a murine study of vaping liquids.

  • Flavors used for exposure included kola, black licorice, banana pudding or cinnacide, both with and without 12 mg/mL of nicotine.
  • Nicotine-free cinnacide exposure reduced airway inflammation and increased peripheral airway hyperresponsiveness.
  • Additionally, banana pudding flavor without nicotine increased soluble lung collagen, and there was a trend toward increased airway inflammation with exposure to nicotine-free black licorice.
  • All e-cigarettes with nicotine were found to suppress airway inflammation but did not affect airway remodeling or hyperresponsiveness.