The study aims to determine whether delayed antibiotics, compared to immediate prescribing, results in decreased antibiotic use and similar clinical improvement in children with mild pneumonia.
RT’s Three Key Takeaways:
- Comparison of Approaches: The study will compare immediate antibiotic prescribing with the SNAP approach, which involves delaying antibiotics unless symptoms worsen, to determine the most effective strategy for managing mild pneumonia in children.
- Focus on Reducing Antibiotic Use: A primary goal of the study is to see if the SNAP approach can significantly reduce unnecessary antibiotic use, which is important for minimizing side effects and combating antibiotic resistance.
- Clinical Outcomes: The research aims to establish whether the SNAP approach can achieve clinical outcomes that are comparable to immediate antibiotic prescribing, ensuring that children’s health is not compromised while reducing antibiotic exposure.
Ann & Robert H. Lurie Children’s Hospital of Chicago, in partnership with University of Utah Health, has been approved for $12 million in research funding by the Patient-Centered Outcomes Research Institute (PCORI) for a study that will compare two ways to use antibiotics in young children with mild pneumonia, one of the leading reasons children seek acute care, who are well enough to be cared for at home.
The first approach is to prescribe and give antibiotics immediately, which is the current standard of care. The second way is to prescribe an antibiotic but not give it unless the child’s symptoms worsen or do not improve within three days, an approach that is known as a Safety-Net Antibiotic Prescription (SNAP).
The study aims to determine whether SNAP, compared to immediate prescribing, results in decreased antibiotic use and similar clinical improvement in children with mild pneumonia.
Rationale Behind the SNAP Approach
“Most pneumonias in young children are caused by a virus, which the body fights off without antibiotics. Despite this, most children with pneumonia are currently treated with antibiotics,” says co-principal investigator Todd Florin, MD, MSCE, associate division head for academic affairs and research in the Division of Emergency Medicine at Lurie Children’s and associate professor of pediatrics at Northwestern University Feinberg School of Medicine, in a release.
He adds, “It is important to avoid exposing children to unnecessary antibiotics for many reasons, including their side effects, such as rashes that can mimic allergies or an upset stomach. We also want to avoid the development of antibiotic-resistant bacteria, a global health threat. A SNAP treatment strategy is currently recommended for ear infections in children and has safely decreased antibiotic use for this condition. This strategy has not been evaluated in pneumonia. We hope our study shows a similar impact and identifies factors that influence implementation of a SNAP strategy.”
The research team is working with 12 pediatric primary care offices and three urgent care centers that are part of the Pediatric Research Consortium at The Children’s Hospital of Philadelphia, and four pediatric emergency departments across the country, including Lurie Children’s and Utah’s Intermountain Primary Children’s Hospital, to enroll 1,823 children between 1 and 6 years of age who have been diagnosed with mild pneumonia.
Study Methodology and Follow-Up
The team will assign children randomly to a group that receives immediate antibiotic prescribing or to a group that uses the SNAP approach.
The research team will follow up with the parent/guardian three times over the 14 days after the child’s appointment to collect information about symptom improvement, antibiotic use, return to healthcare, child quality of life, parent satisfaction, and antibiotic side effects. The research team will also study how SNAP is implemented by talking to parents/guardians and pediatricians about factors that might make it easier or harder to use this approach.
Informed by Patient and Clinician Input
“The decision to compare immediate antibiotic prescribing and the SNAP approach was informed by our research on how parents and pediatricians feel about navigating the care of children with pneumonia in real-world settings,” says co-principal investigator Julia E. Szymczak, PhD, associate professor of epidemiology and co-director of the Utah Quality Advancement Laboratory in the Department of Internal Medicine at the Spencer Fox Eccles School of Medicine at U of U Health, in a release.
Szymczak continues, “It is important for researchers to generate evidence that patients and clinicians need to guide difficult healthcare decisions, such as when to use an antibiotic. Nobody wants to give unnecessary medicine, but it is scary to care for a child with pneumonia. And it’s often unclear whether an antibiotic will help. SNAP empowers parents to give their child a chance to fight off the infection on their own while also having fast access to antibiotics if it becomes clear they are needed.”
The study was selected through PCORI’s review process in which patients, caregivers, and other stakeholders join scientists to evaluate proposals. The award has been approved pending completion of PCORI’s business and programmatic review and issuance of a formal award contract.
PCORI is an independent, nonprofit organization authorized by Congress with a mission to fund patient-centered comparative clinical effectiveness research that provides patients, their caregivers, and clinicians with evidence-based information to make better-informed health and health care decisions.
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