Nonsteroidal anti-inflammatory drug (NSAID) use during acute respiratory infection (ARI) increases the risk for acute myocardial infarction (AMI) 3.4-fold if taken by mouth and 7.2-fold with parenteral dosing compared with baseline risk without NSAID use or ARI, according to a report published online February 2 in the Journal of Infectious Diseases.

Compared with no exposure, NSAID use during ARI was associated with a 3.4-fold increased risk for AMI (adjusted odds ratio [aOR], 3.41; 95% confidence interval [CI], 2.80 – 4.16), ARI without NSAIDs was associated with a 2.7-fold increased risk for AMI (aOR, 2.65; 95% CI, 2.29 – 3.06), and NSAID use alone was associated with a 1.5-fold increased risk (aOR, 1.47; 95% CI, 1.33 – 1.62).