The cholesterol-lowering drug rosuvastatin (Crestor, AstraZeneca) edged out the hypothyroid drug levothyroxine (Synthroid, AbbVie) as the most prescribed drug in the United States, according to a rolling 12-month history (Oct 2013 to Sept 2014) of the top 100 drugs in the United States. Rosuvastatin and levothyroxine both had about 22.3 million prescriptions.

Notably, asthma medications albuterol (Ventolin HFA, GlaxoSmithKline) ranked #4 at about 17.8 million prescriptions and fluticasone propionate/salmeterol (Advair Diskus, GlaxoSmithKline) ranked #5 at about 14.5 million prescriptions.

COPD medication tiotropium bromide (Spiriva Handihaler, Boehringer Ingelheim Pharmaceuticals) ranked #9 with about 9.5 million prescriptions. Other respiratory-related medications like Flovent, Symbicort, Nasonex, Tamiflu, and Chantix were also highly-prescribed.

In total, the top 100 drugs accounted for over 435 million prescriptions.