Tecovirimat Safe But Ineffective Against clade II mpox
The Study of Tecovirimat for Mpox (STOMP) began in September 2022 as part of the US whole-of-government response to the clade II mpox outbreak.
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Clinical Trials
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Tecovirimat Safe But Ineffective Against clade II mpox
The Study of Tecovirimat for Mpox (STOMP) began in September 2022 as part of the US whole-of-government response to the clade II mpox outbreak.
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Inhaled COVID Vaccine Begins Recruitment for Phase 2 Trial
The phase 2 The AeroVax study will evaluate the safety and effectiveness of a novel inhaled COVID-19 vaccine.
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Tezspire Significantly Reduced Nasal Congestion, Polyp Size in CRwNP Patients
Tezspire, an add-on maintenance treatment of adult and pediatric patients aged 12 years and older with severe asthma, showed significant benefits for patients with chronic rhinosinusitis with nasal polyps (CRSwNP) in a Phase 3 clinical trial.
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Study Compares Xolair to Oral Immunotherapy in Treating Food Allergies
Xolair was superior to oral immunotherapy in both effectiveness and fewer side effects for people with one or more food allergies.
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Novel Bone Marrow Transplant Can Cure Sickle Cell Disease
A novel transplant procedure using bone marrow from a “half-matched” donor is safe and curative for adults with sickle cell disease, as well as more affordable than recently approved gene therapy products for SCD.
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Nasal COVID-19 Vaccine to Enter Clinical Trials
The FDA approved an investigational new drug application from Ocugen Inc for a nasal COVID-19 vaccine that will begin a Phase 1 clinical trial.
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Drug Candidate Improves Lung Function in Long COVID Patients
The investigational treatment improved lung function and quality of life in previously hospitalized COVID-19 patients with long-term pulmonary complications.
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First Patient Dosed in Study of Nicotine Inhaler for Smoking Cessation
The phase 1 trial evaluates the nicotine inhaler as a smoking cessation therapy, aiming to improve nicotine delivery and support smokers in quitting.
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Tivoxavir Marboxil Shows Promise as Potential One-Time Treatment for H5N1
A phase 1 trial of the investigational therapy for H5N1 bird flu showed promising safety, tolerability, and pharmacokinetic results, with the company securing financing to advance its development.
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Novavax Begins Phase 3 Trial for COVID-19-Flu Combo Vaccine
Novavax has begun a phase 3 trial evaluating its COVID-19-influenza combination vaccine in adults aged 65 and older.
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Benralizumab Outperforms Steroids in Treating Asthma and COPD Flare-Ups
Benralizumab injection improved respiratory symptoms within 28 days and reduced treatment failures by fourfold after 90 days compared to standard steroid therapy.
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NIH Trial Halts After Smallpox Drug Fails to Show Benefit for Mpox
A clinical trial testing a smallpox antiviral for mpox was halted after interim findings showed no efficacy in reducing lesion resolution or pain in mild to moderate cases.
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FDA OKs Phase 1 Trial for mRNA Vaccine for H5N1 Avian Flu
A self-amplifying mRNA vaccine candidate for H5N1 avian influenza is set to begin phase 1 trials in the US after receiving FDA approval to proceed.
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Phase 1 Study of Inhaled Peptide Therapy for Cystic Fibrosis Begins
The study will evaluate the safety and tolerability of an inhaled peptide therapy designed to enhance CFTR function, act as a bronchodilator, and reduce inflammation.
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Mpox Vaccine Safe and Effective in Adolescents, Interim Analysis Shows
The NIH clinical trial aims to address a knowledge gap on mpox vaccine use in adolescent populations.
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FDA Places Hold on Novavax’s COVID-Flu Vaccine IND After Adverse Event
The FDA has placed a hold on Novavax’s Investigational New Drug application for its COVID-19-influenza combination and stand-alone influenza vaccines following a report of an adverse event in a participant from the completed combination trial.
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Drug Candidate Enters Phase 3 Trial to Prevent BPD in Preterm Infants
The trial will assess the efficacy of the drug, which has been granted orphan drug designation, when added to the standard of care in preventing or reducing the severity of bronchopulmonary dysplasia.
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Investigational Brensocatib Reduces Exacerbations Across Most Bronchiectasis Subgroups
New sub-analyses show that brensocatib reduced pulmonary exacerbations and slowed lung function decline for most subgroups of patients with non-cystic fibrosis bronchiectasis.
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Arexvy RSV Vaccine Shows Protection Over Three Seasons
Cumulative efficacy over three RSV seasons was clinically meaningful at 62.9% against RSV-LRTD after a single dose of the vaccine.
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Airsupra Rescue Inhaler Reduces Risk of Severe Asthma Exacerbations
AstraZeneca’s inhaled anti-inflammatory rescue medication demonstrated significant benefit compared to albuterol in a phase IIIb trial.
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Oral COVID-19 Drug Candidate Ratutrelvir Shows Promise in Early Trial
Topline results demonstrated that the drug was well-tolerated over a 10-day period and achieved consistent plasma levels without the need for ritonavir co-administration.
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Enrollment Completed Early for Phase 3 Study of Oral Sleep Apnea Treatment
Apnimed announced the early completion of enrollment for its phase 3 trial to evaluate the efficacy and safety of AD109 for obstructive sleep apnea.
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Epilepsy Drug Improves Sleep Apnea Symptoms in Trial
People taking the drug had fewer pauses in their breathing and higher levels of oxygen in their blood during sleep.
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AN2 Therapeutics Stops Phase 2/3 Epetraborole Trial for MAC Lung Disease
The EBO-301 study is being discontinued following topline results from the phase 2 part of the study in treatment-refractory patients with MAC lung disease.
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