Women who received a high dose of vitamin D while pregnant did not achieve a statistically significant decrease in the risk for having children who developed asthma within the first 3 years of life, according to results from a randomized, double blind, placebo-controlled trial.

“In pregnant women at risk of having a child with asthma, supplementation with 4,400 IU [per day] of vitamin D compared with 400 IU [per day] significantly increased vitamin D levels in the women,” Augusto A. Litonjua, MD, MPH, of the Channing division of network medicine, and department of medicine at Brigham and Women’s Hospital in Boston, and colleagues wrote.

“The incidence of asthma and recurrent wheezing in their children at age 3 years was lower by 6.1%, but this did not meet statistical significance; however, the study may have been underpowered. Longer follow-up of the children is ongoing to determine whether the difference is clinically important.”

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