An asthma exacerbation resulting in hospitalization greatly increases the risk for acute myocardial infarction and ischemic stroke in adults with poorly controlled asthma, according to study results published in the Journal of Allergy and Clinical Immunology: In Practice.

The Healthcare Cost and Utilization Project (HCUP) State Inpatient Database (SID) was used to enroll adults aged ?40 years with poorly controlled asthma and a history of ?1 hospitalization for asthma exacerbation. A total of 4607 patients from Florida, Nebraska, and New York, who were hospitalized and experienced their first subsequent episode of acute MI or ischemic stroke, were identified.

A composite of acute MI and ischemic stroke comprised the primary outcome of interest. A regression analysis was used to compare incidence rates of the primary outcome during days 1 to 7, 8 to 14, and 15 to 28 after asthma exacerbation with a reference period, or the period before and after the 3 risk periods.