The FDA ordered three small e-cigarette companies not to sell their flavored products, a move that could signal a larger crackdown.

Under the FDA’s orders, the manufacturers — JD Nova Group LLC, Great American Vapes and VaporSalon — must pull 55,000 existing or planned flavored products from the market or risk enforcement.

Regulators said the companies’ applications failed to provide “sufficient evidence” that their products provide a net public health benefit for adult smokers compared with the “threat posed by the well-documented, alarming levels of youth use” of flavored vapes.

The agency’s orders, which were its first marketing denials for e-cigarettes, singled out the companies for selling vapes that come in flavors such as Apple Crumble, Dr. Cola and Cinnamon Toast Cereal.

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