Interventional reduction of the angiopoietin-1/angiopoietin-2 ratio may provide a therapeutic perspective for prevention of acute lung injury in pneumonia, according to a study published in the American Journal of Respiratory and Critical Care Medicine.

In newly diagnosed patients with pneumonia, CRB-65 and CURB-65 scores are recommended in international guidelines and CRB-65 is widely used as a predictor of death. Both scores are comparable for mortality prediction, but provide insufficient prediction power of 30-day mortality or intensive care unit (ICU) admission. The identification and addition of specific biomarkers may improve the accuracy of both CRB-65 and CURB-65 scores.

In this holistic analysis, clinical data combined with comprehensive in vivo and in vitropathomechanistic experiments evaluated the prognostic and pathogenic effect of angiopoietins in regulating pulmonary vascular barrier function and inflammation in bacterial pneumonia.